Molecular profiling plays a crucial role in optimizing cancer care by enabling personalized treatment decisions, improving treatment outcomes, and offering potential avenues for targeted therapies and clinical trial participation. In this PCPA Podcast, Professor Desmond Yip, PCPA Secretary and Treasurer and Senior Staff Specialist in Medical Oncology at the Canberra Hospital is joined by Professor Lorraine Chantrill, Senior Staff Specialist Medical Oncologist and Head of Service for Medical Oncology across the Illawarra Shoalhaven Local Health District (ISLHD), and Area Clinical Director of Clinical Trials and also Dr Vivek Rathi, Director of Operations, Group Medical Director, Group Molecular Pathologist at LifeStrands Genomics. In this podcast, they discuss precision medicine for Australian patients with cancer, current genetic pathology and actionable targets. We look to the future of comprehensive genomic profiling (CGP) and how to make this a clinical solution for all. The PCPA is a dynamic, not-for-profit Oncology specialist organisation that aims to improve the care of cancer patients in the private health system, believing that cancer care should be the best it can be for our patients, their families and our members who are entrusted to care for them.